PUBLICATIONS
Lipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders
Estela Area-Gomez, D Larrea, T Yun, Y Xu, J Hupf, F Zandkarimi, R B Chan, H Mitsumoto
Sci Rep . 2021 Jun 30;11(1):13562. doi: 10.1038/s41598-021-92112-3.
The Alzheimer's disease-associated C99 fragment of APP regulates cellular cholesterol trafficking
Jorge Montesinos, Marta Pera, Delfina Larrea, Cristina Guardia-Laguarta, Rishi R Agrawal, Kevin R Velasco, Taekyung D Yun, Irina G Stavrovskaya, Yimeng Xu, So Yeon Koo, Amanda M Snead, Andrew A Sproul, Estela Area-Gomez
EMBO J. 2020 Oct 15;39(20):e103791. doi: 10.15252/embj.2019103791
The fat brain
Jorge Montesinos, Cristina Guardia-Laguarta, Estela Area-Gomez
Curr Opin Clin Nutr Metab Care . 2020 Mar;23(2):68-75
MAM and C99, key players in the pathogenesis of Alzheimer's disease
Marta Pera, Jorge Montesinos, Delfina Larrea, Rishi R Agrawal, Kevin R Velasco, Irina G Stavrovskaya, Taekyung D Yun, Estela Area-Gomez
PMID: 32739006 DOI: 10.1016/bs.irn.2020.03.016
Int Rev Neurobiol. 2020;154:235-278. doi: 10.1016/bs.irn.2020.03.016.
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice.
Area-Gomez E, Larrea D, Pera M, Agrawal RR, Guilfoyle DN, Pirhaji L, Shannon K, Arain HA, Ashok A, Chen Q, Dillman AA, Figueroa HY, Cookson MR, Gross SS, Fraenkel E, Duff KE, Nuriel T.
Sci Rep. 2020 Mar 9;10(1):4277. doi: 10.1038/s41598-020-61142-8.
Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas.
Area-Gomez E, Guardia-Laguarta C, Schon EA, Przedborski S.
J Clin Invest. 2019 Jan 2;129(1):34-45. doi: 10.1172/JCI120848. Epub 2019 Jan 2
A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease.
Area-Gomez E, de Groof A, Bonilla E, Montesinos J, Tanji K, Boldogh I, Pon L, Schon EA.
Cell Death Dis. 2018 Feb 28;9(3):335. doi: 10.1038/s41419-017-0215-0
Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.
Pera M, Larrea D, Guardia-Laguarta C, Montesinos J, Velasco KR, Agrawal RR, Xu Y, Chan RB, Di Paolo G, Mehler MF, Perumal GS, Macaluso FP, Freyberg ZZ, Acin-Perez R, Enriquez JA, Schon EA, Area-Gomez E.
EMBO J. 2017 Nov 15;36(22):3356-3371. doi: 10.15252/embj.201796797. Epub 2017 Oct 10.
Alzheimer Disease.
Area-Gomez E, Schon EA.
Adv Exp Med Biol. 2017;997:149-156. doi: 10.1007/978-981-10-4567-7_11.
On the Pathogenesis of Alzheimer's Disease: The MAM Hypothesis.
Area-Gomez E, Schon EA.
FASEB J. 2017 Mar;31(3):864-867. doi: 10.1096/fj.201601309.
Mitochondria-associated ER membranes and Alzheimer disease.
Area-Gomez E, Schon EA.
Curr Opin Genet Dev. 2016 Jun;38:90-96. doi: 10.1016/j.gde.2016.04.006. Epub 2016 May 25.
Assessing the function of mitochondria-associated ER membranes.
Area-Gomez E.
Methods Enzymol. 2014;547:181-97. doi: 10.1016/B978-0-12-801415-8.00011-4.
Mitochondrial genetics and disease.
Area-Gomez E.
Methods Enzymol. 2014;547:181-97. doi: 10.1016/B978-0-12-801415-8.00011-4.
Mitochondria-associated ER membranes in Alzheimer disease.
Schon EA, Area-Gomez E.
Mol Cell Neurosci. 2013 Jul;55:26-36. doi: 10.1016/j.mcn.2012.07.011. Epub 2012 Aug 24.
Upregulated function of mitochondria-associated ER membranes in Alzheimer disease.
Area-Gomez E, Del Carmen Lara Castillo M, Tambini MD, Guardia-Laguarta C, de Groof AJ, Madra M, Ikenouchi J, Umeda M, Bird TD, Sturley SL, Schon EA.
EMBO J. 2012 Nov 5;31(21):4106-23. doi: 10.1038/emboj.2012.202. Epub 2012 Aug 14.
Is Alzheimer's disease a disorder of mitochondria-associated membranes?
Schon EA, Area-Gomez E.
J Alzheimers Dis. 2010;20 Suppl 2:S281-92. doi: 10.3233/JAD-2010-100495.
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.
Area-Gomez E, de Groof AJ, Boldogh I, Bird TD, Gibson GE, Koehler CM, Yu WH, Duff KE, Yaffe MP, Pon LA, Schon EA.
Am J Pathol. 2009 Nov;175(5):1810-6. doi: 10.2353/ajpath.2009.090219. Epub 2009 Oct 15.